Describe the Krebs cycle.

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(N/A) The $TCA$ cycle starts with the condensation of an acetyl group with oxaloacetic acid $(OAA)$ and water to yield citric acid. The reaction is catalyzed by the enzyme citrate synthase, and a molecule of $CoA$ is released.
$OAA (4C) + \text{Acetyl } CoA + H_2O (2C) \xrightarrow{\text{Citrate synthase}} \text{Citric acid } (6C) + CoA$
Citrate is then isomerized to isocitrate.
It is followed by two successive steps of decarboxylation, leading to the formation of $\alpha$-ketoglutaric acid and then succinyl-$CoA$.
$\text{Citric acid} \rightarrow \text{Isocitrate} \rightarrow \alpha\text{-ketoglutaric acid}$
Remaining steps of the citric acid cycle:
Succinyl-$CoA$ is oxidized to $OAA$, allowing the cycle to continue.
During the conversion of succinyl-$CoA$ to succinic acid, a molecule of $GTP$ is synthesized. This is a substrate-level phosphorylation.
In a coupled reaction, $GTP$ is converted to $GDP$ with the simultaneous synthesis of $ATP$ from $ADP$.
$GTP \rightarrow GDP + Pi \rightarrow ADP + Pi \rightarrow ATP$
Also, there are three points in the cycle where $NAD^+$ is reduced to $NADH + H^+$ and one point where $FAD^+$ is reduced to $FADH_2$. The continued oxidation of acetyl $CoA$ via the $TCA$ cycle requires the continued replenishment of oxaloacetic acid.
It is the first member of the cycle. In addition, it also requires the regeneration of $NAD^+$ and $FAD^+$ from $NADH$ and $FADH_2$, respectively.
The summary equation for this phase of respiration may be written as follows:
$\text{Pyruvic acid} + 4NAD^+ + FAD^+ + 2H_2O + ADP + Pi \xrightarrow{\text{Mitochondrial Matrix}} 3CO_2 + 4NADH + 4H^+ + FADH_2 + ATP$
Glucose has been broken down to release $CO_2$, and eight molecules of $NADH + H^+$; two of $FADH_2$ have been synthesized besides just two molecules of $ATP$ in the $TCA$ cycle.

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Similar Questions

Citrate,the first stable product of the Krebs cycle,undergoes how many oxidation and decarboxylation steps respectively to regenerate oxaloacetate?

$FADH_2$ is produced during which of the following reactions?

In $Kreb's$ cycle, $FAD$ acts as an electron acceptor during the conversion of:

Each molecule of pyruvic acid entering the Kreb's cycle produces:

Which statement is wrong for Krebs' cycle?

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